Discovery and synthesis of sulfur-containing 6-substituted 5, 8-dimethoxy-1, 4-naphthoquinone oxime derivatives as new and potential anti-MDR cancer agents
Multi-drug resistance (MDR) to anticancer drugs is the primary impediment to successful
treatment of cancer. Hunting for new compounds with potent anti-MDR activity is an effectual
approach to conquer cancer drug resistance. In this work, 33 new sulfur-containing 1, 4-
naphthoquinone oxime derivatives were prepared and investigated for their cytotoxicity
against a panel of tumor cell lines and fibroblast normal cell line. Cell-based assay showed
that most of target compounds displayed more potent cytotoxic potency than positive …
treatment of cancer. Hunting for new compounds with potent anti-MDR activity is an effectual
approach to conquer cancer drug resistance. In this work, 33 new sulfur-containing 1, 4-
naphthoquinone oxime derivatives were prepared and investigated for their cytotoxicity
against a panel of tumor cell lines and fibroblast normal cell line. Cell-based assay showed
that most of target compounds displayed more potent cytotoxic potency than positive …
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